The 10 Greatest Scientist in the world which is Contribution in Cell Biology

Get to know the scientists that changed the world as we know it though their contributions and discoveries in Cell Biology.

The cell (from Latin cella, meaning “small room”) is the basic structural, functional, and biological unit of all known organisms. Cells are the smallest units of life, and hence are often referred to as the “building blocks of life”. The study of cells is called cell biology, cellular biology, or cytology.

Contribution of Scientists in Cell Biology

  • Zacharias Janssen
In 1595 – Jansen Discovered 1st compound microscope

A Dutch father-son team named Hans and Zacharias Janssen invented the first so-called compound microscope in the late 16th century when they discovered that, if they put a lens at the top and bottom of a tube and looked through it, objects on the other end became magnified.

  • Robert Hooke
Robert Hooke Discover ‘cells’ in cork.

Robert Hooke is known as a “Renaissance Man” of 17th century England for his work in the sciences, which covered areas such as astronomy, physics and biology.Scientist Robert Hooke was educated at Oxford and spent his career at the Royal Society and Gresham College. His research and experiments ranged from astronomy to biology to physics; he is particularly recognized for the observations he made while using a microscope and for “Hooke’s Law” of elasticity. Hooke died in London in 1703.

  • Antonie van Leeuwenhoek

In 1674 He discovered protozoa.Antonie van Leeuwenhoek was born in Delft on 24 October 1632. … As well as being the father of microbiology, van Leeuwenhoek laid the foundations of plant anatomy and became an expert on animal reproduction. He discovered blood cells and microscopic nematodes, and studied the structure of wood and crystals.

  • Robert Brown
In 1833 Brown described the cell nucleus in cells of the orchid.

Scottish botanist Robert Brown (1773-1858) was responsible for discovering the nucleus of a cell, he is perhaps best known for his discovery of the random movement of microscopic particles in a surrounding solution, later referred to as “Brownian motion.” He also developed alternative plant classification .



  • Schleiden and Schwann
In 1838 Schleiden and Schwann proposed cell theory.

Schwann’s theory and observations became the foundation of modern histology.  1839: Theodor Schwann and Matthias Jakob Schleiden elucidate the principle that plants and animals are made of cells, concluding that cells are a common unit of structure and development, and thus founding the cell theory.

  • Albert von Kölliker
In 1857 – Kolliker described mitochondria

One of Kölliker’s most important contributions was the development of cell theory. He helped to confirm the view that cells arise only from other cells and cannot be generated from non-cellular material. He also advocated the view that tissue should be studied and understood as a mass of individual cells.



  • Walther Flemming
In 1879 – Flemming described chromosome behavior during mitosis

Flemming was the first to detail the chromosomal movements in the process of mitosis. In 1879, Flemming used aniline dyes, a by-product of coal tar, to stain cells of salamander embryos. He was able to visualize the threadlike material as the cells divide. Flemming pioneered the use of synthetic aniline dyes to visualize the nucleus during cell division. Flemming observed that the red dye was heavily absorbed by granular-appearing structures in the nucleus, and named these structures chromatin, from the Greek word for color.

  • Werner von Siemens
In 1939 – Siemens produced the first commercial transmission electron microscope.

As one of the world’s biggest producers of energy-efficient, resource-saving technologies, Siemens is a pioneer in infrastructure and energy solutions, automation and software for industry and is a leader in medical diagnosis.He invents Speaker, Electromote and third Train.

  • Roger Y. Tsien
In 1995 – Tsien identifies mutant of GFP with enhanced spectral properties

Roger Y. Tsien, who won a Nobel Prize in Chemistry for creating a rainbow of fluorescent proteins that could light up the dance of molecules within cells, died on Aug. 24 in Eugene, Ore. … While other scientists made the initial discoveries of a green fluorescent protein from jellyfish. Gfp refers to the gene that produces green fluorescent protein. Using DNA recombinant technology, scientists combine the Gfp gene to a another gene that produces a protein that they want to study, and then they insert the complex into a cell.

  • Hamilton and Baulcombe
In 1999 – Hamilton and Baulcombe discover siRNA as part of post-transcriptional gene silencing (PTGS) in plants

Hamilton & Baulcombe revealed that a predominantly 21 nucleotide (nt) short RNA species could be detected in all examined silenced plants, but was missing from the non-silenced plants. These 21 nt RNA molecules were sequence-specific for the gene targeted by PTGS and both sense and antisense strands were present.






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